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  In Vivo Citrex evaluation

DRINKING WATER: Citrex™ liquid effect on the treatment of turkeys artificially infected with S. tyhimurium.

S. typhimurium isolation from cloacal swabs and internal organs of 6 week-old turkeys, 1 and 7 days post challenge (PC) after treatment with Citrex™ in the drinking water.

# of Samples / Positive Samples
Treatment 1 day PC 7 days PC 7 days PC
  Cloacal Swab Internal Organs Cloacal Swab
I. Control 3/0 1/0 3/0
II. ST 3/3 1/1 3/3
III: Citrex + ST 4/4 1/1 4/2

Challenge: Intubation into the crop with 1 ml of ST (6x109 CFU/ml).
Citrex Dosage: 100 ppm in drinking water administered daily ad libitum.

Isolation of ST in cloacal # of birds tested/positive samples swabs 21 days PC in
c ommercialturkeys separated from treatments 2 and 3 and treated with Citrex™ during 14 days in the drinking water.

Treatment # of birds tested/positive samples
I. Control Not tested
II. ST 5/3
III: Citrex + ST 5/0


EXPERIMENT CONCLUSION

Citrex™ eliminated ST intestinal colonization permanently after 14 days of treatment. Fecal shedding was reduced in half when birds in T2 and T3 were treated with Citrex™ for 7 days.

Reference: “Effect of an ultrabiotic on Salmonella typhimurium colonization and blood composition in turkeys experimentally challenged.”

A. Koncicki1, B. Mazur-Gonkowska1, A. Krasnodebska-Depta1, and M. Contreras.
2International Poultry Forum, Atlanta, Georgia, US, 2006. 1 Departament of Avian Medicine, University of Warmia and Mazury, Olsztyn, Poland. 2 Citrex Inc., Miami, Florida, USA

FEED: Citrex™ powder effect on prevention and treatment of broilers experimentally infected with S. enteritidis.

Effect of Citrex™ powder administration in the diet of 19 day-old commercial broilers on the transmission of SE after challenge at 1 day of age.

Challege: Intubation into the crop with 1 ml of S. enteritidis (106 CFU/ml) at 1 day of age. Only the first 4 birds in each group were challenged experimentally, the rest were infected naturally (horizontal transmission).

Citrex Dosage: 125 g/MT (ppm) from day 1.

Citrex
Treatment
    Control    
Bird # Spleen Bird #
Isolation
Cecum
Isolation
Bird # Spleen
Isolation
Cecum
Isolation
1 N + 1 -- P
2   -- 2 +  
3 E -- 3 -- 0
4   + 4 --  
5 G + 5 -- S
6   -- 6 --  
7 A + 7 -- I
8   + 8 --  
9 T + 9 -- T
10   -- 10 --  
11 I + 11 -- I
12   -- 12 --  
13 V + 13 -- V
14 E -- 14 -- E


EXPERIMENT CONCLUSION

In two out of the 4 broilers directly challenged with SE, Citrex™ eliminated intestinal colonization (ceca). A statistically-significant difference was reported between the group treated with Citrex™ and the nontreated group. In the case of the broilers contaminated horizontally and treated with Citrex™, a statistically significant reduction in the number of infected birds was detected when compared to the non-treated birds.


Reference: Institut de Recerca i Techologia Agroalimentaries (IRTA). Barcelona, Spain. 1999.


 
     
   
   
 
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