IN VIVO SCIENTIFIC TESTS
Some scientific studies showing the efficacy of MYCO-AD® in the control of the most important
mycotoxins affecting commercial birds are shown below.
Evaluation of Myco-Ad efficacy in decreasing the toxicity of t-2 toxin in commercial broilers
Facilities: Veterinary Medicine Institute,
Debrecen, Hungry, & International Animal
Research Institute, Querétaro, Mexico.
Type of Birds: Broilers
MYCO-AD® Inclusion rate: 2.5 kg per metric
ton of feed.
Concentration of natural and synthetic
mycotoxins in the feed: T-2 Toxin 1.0 and 1.25 ppm, respectively.
High levels were used in order to show the
damage caused by these mycotoxins.
Under field conditions, lower levels of
natural mycotoxins can cause damage
more readily.
Reference: A. Casarin, M. Forat, E. Soto,
B. Fazekas, J. Tanyi, and D. Zaviezo.
Evaluation of the efficacy of a commercial
HSCAS to reduce toxicity of T-2 toxin in
broiler chicks. 2005 International Poultry
Scientific Forum. Atlanta, GA, USA.
Table 5. Effects of MYCO-AD on body weight, feed intake, feed conversion rate (FCR), and
organs development of broilers fed T-2 toxin at 40 days of age.
| TREATMENT |
Body
weight
g |
Feed
Intake
g |
FCR |
Spleen
weight/
100g BW |
Liver
weight/
100g BW |
Heart
weight/
100g BW |
| Control |
1791 a |
369 0 a |
2.06 a |
0.12 a |
2.5 a |
0.6 a |
Control +
T-2 (1 ppm) |
1381 b |
292 8 b |
2.12 b |
0.09 b |
2.5 a |
0.6 a |
Control + T-2
+ ® MYCO-AD |
1840 a |
371 7 a |
2.02 a |
0.12 a |
2.4 a |
0.6 a |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Table 6. Effects of MYCO-AD on body weight (BW), oral lesions, and bursal development of
broiler chickens fed T-2 toxin at different ages.
| |
21 Days |
28 Days |
35 Days |
| TREATAMENT |
BW
g |
Oral lesion |
Bursal
weight/
100g BW |
BW
g |
Oral lesion |
Bursal
weight/
100g BW |
BW
g |
Oral lesion |
| Control |
538 a |
0 a |
0.30 a |
932 a |
0 a |
0.45 a |
1446 a |
0 a |
Control + T2
(1 ppm) |
463 b |
1.84 b |
0.20 b |
788 b |
1.63 b |
0.20 b |
1148 a |
0.96 b |
| Control + T2 +MYCO-AD |
543 a |
0.36 a |
0.28 a |
938 a |
0.21 a |
0.40 a |
1451 a |
0.04 a |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Graph 1. Incidence and severity of oral lesions in broilers fed the control diet, the T- 2 toxin
contaminated diet, and the T-2 toxin contaminated diet treated with MYCO-AD® during the
entire test.
Table 7. Effects of MYCO-AD on average daily gain (ADG), daily feed intake (DFI), feed
conversion rate (FCR), oral lesions, and bone mineralization of 38 day-old broilers exposed to
test diets for 33 days.
| TREATMENT |
ADG
g |
DFI
g |
FCR |
Oral
lession |
Bone
ash
% |
| Control |
54.8 a |
105. 3 a |
1.92 a |
0.2 5 a |
45.9 5 a |
| MYCO-AD |
51.3 a |
103.0 a |
2.01 a |
0.25 a |
45.65 a |
| Toxin T-2 (1.25 ppm) |
44.9 b |
98.4 a |
2.19 b |
2.75 c |
-- |
| MYCO-AD + Toxin T-2 (1.25 ppm) |
53.5 a |
101.4 a |
1.90 a |
1.75 b |
-- |
a, b, c Values within one column with different letters are significantly different (P< 0.05).
Conclusions
Effect on T-2 Toxin
MYCO-AD® controlled in a statistically
significant manner the deleterious effects
caused by T-2 toxin on broiler performance.
In the presence of the mycotoxin, MYCO-AD®
prevented bursal atrophy and significantly
decreased the level of oral lesions in birds.
Nutrient absorption
No negative effects were seen on the
productive parameters of MYCO AD® treated
birds. Results were statistically similar to
those of the controls. Similarly, no
statistically significant differences were
observed when bone mineralization was
determined at trial completion.
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